Identification of nanometre-sized ultra-high molecular weight polyethylene wear particles in samples retrieved in vivo

Identification of nanometre-sized ultra-high molecular weight polyethylene wear particles in samples retrieved in vivo.

Nanometre-sized particles of ultra-high molecular weight polyethylene have been identified in the lubricants retrieved from hip simulators. Tissue samples were taken from seven failed Charnley total hip replacements, digested using strong alkali and analysed using high-resolution field emission gun-scanning electron microscopy to determine whether nanometre-sized particles of polyethylene debri...

Wear of Ultra High Molecular Weight Polyethylene

Generation of a large volume of clinically relevant nanometre-sized ultra-high-molecular-weight polyethylene wear particles for cell culture studies

It has recently been shown that the wear of ultra-high-molecular-weight polyethylene in hip and knee prostheses leads to the generation of nanometre-sized particles, in addition to micron-sized particles. The biological activity of nanometre-sized ultra-high-molecular-weight polyethylene wear particles has not, however, previously been studied due to difficulties in generating sufficient volume...

An In Vivo Model of Continuous Infusion of Ultra High Molecular Weight Polyethylene Particles

Introduction: Wear particles from orthopaedic implants have been shown to affect both initial osseointegration and subsequent bone remodeling of total joint replacements (TJRs). Continued production and exposure to particles over time adversely affects bone formation and resorption, resulting in periprosthetic osteolysis. Current animal models of particle-induced periprosthetic osteolysis have ...

Ultra high molecular-weight polyethylene (UHMWPE) in total knee replacement: fabrication, sterilisation and wear.

THE JOURNAL OF BONE AND JOINT SURGERY G. Blunn, PhD, Professor The Centre for Biomedical Engineering, Institute of Orthopaedics, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK. E. M. Brach del Preva, MD, Associate Professor Department of Traumatology and Orthopaedics, University of Turin, Via Zuretti 29, 10126 Turin, Italy. L. Costa, PhD, Professor IFM Chemistry Department, University of Turin,...